Expression profile of genes regulating cellular response to cytokine stimulus in Sjögren’s syndrome

Abstract The existence of abnormal cytokine profile in Sjögren’s syndrome (SS) may contribute to find potential SS biomarkers and accompanying comorbidities. We aimed investigate compare gene expressions the labial salivary glands healthy subjects (HS) by means microarray analysis. study group comprised 8 patients HS relative expression changes were validated with real time quantitative polymerase chain reaction 25 20 HS. Among differently expressed genes belonging “cellular response stimulus”, “cytokine-mediated signaling pathway” “innate immune response” ontology groups a fold change >1.5 p value < 0.05, adiponectin, C1Q collagen domain containing (ADIPOQ), S100 calcium binding protein A9 (S100A9), leptin receptor (LEPR), fatty acid 4 (FABP4) higher than Increased assessed are determined presence inflammation be valuable diagnostic biomarker SS. Their selected systemic effects suggest their role as prognostic risk accelerated atherosclerosis cardiovascular complications